Apalachicola makes a great base camp for adventures around Apalachicola Bay. It’s a very walkable historic city with a quaint waterfront downtown. It’s the place where air conditioning was invented, and there’s a museum for that. Oysters dominate restaurant menus, as the bay has traditionally been Florida’s best oyster grounds.
While distant from any other cities in the Florida Panhandle, it’s a short hop over the long bridge and causeway to get to the fishing village of Eastpoint, which in turn provides access to the Apalachicola National Forest and Tates Hell State Forest.
Across the bay bridge from Eastpoint is St. George Island, a popular vacation getaway with a must-visit state park. Stretching east, west, and upriver, the Apalachicola National Estuarine Research Reserve blankets nearly a quarter million miles of marine basin, and is a UNESCO Biosphere Reserve. Its headquarters is in Eastpoint.